D398 HLTH 2422
Introduction to Pharmacology
OA READINESS EXAM
Q & S
©2025/2026
1. Which pharmacokinetic parameter is primarily
responsible for the rate at which a drug reaches systemic
circulation?
 - A) Clearance
 - B) Volume of Distribution
 - C) Bioavailability
 - D) Half-Life

 Answer: C) Bioavailability
 Rationale: Bioavailability refers to the fraction of an
administered dose of an unchanged drug that reaches the
systemic circulation, indicating the rate and extent of drug
absorption.
2. Which phase of clinical drug trials primarily assesses the
safety and pharmacokinetics of a drug in healthy
volunteers?
 - A) Phase I
 - B) Phase II
 - C) Phase III
 - D) Phase IV

 Answer: A) Phase I
 Rationale: Phase I trials are conducted to assess the
safety, tolerability, pharmacokinetics, and
pharmacodynamics of a drug in a small group of healthy
individuals.
3. A patient presents with liver impairment. Which
pharmacokinetic process is most likely to be affected?
 - A) Absorption