NURS 8024 (Medicine) Advanced Pharmacology Definitions and Concepts Week 1 Summary A+ GRADED.
Competition for Plasma Protein Binding: Class II (minority of drugs)
✔✔-High dose/capacity ratio
-Amount of drug > albumin binding capacity
-High proportion of drug in "free" state = not protein bound
Clinical Implications of Plasma Protein Binding
✔✔Drug displacement from albumin substantial
source of drug interactions.....
• Class I drug - warfarin
• Highly protein bound - small fraction of free drug in plasma
↓
• Class II drug given - sulfa
• Displaces warfarin from albumin
• Rapid rise in free drug concentration
• Increased therapeutic effect- toxic effect
Drug Displacement and Vd
✔✔--Dependent on Vd and therapeutic index of drug
--Large Vd verses small Vd (drug is less around)

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