NURS 215 FUNDAMENTALS OF NURSING LATEST UPDATED FINAL EXAM STUDY GUIDE ARIZONA COLLEGE OF NURSING
Additional Pharmacokinetic Factors Specific to Children
✔✔Decreased gastric acid production and slower gastric emptying time
Decreased first-pass medication absorption due to immaturity of the liver
Increased absorption of topical medications (greater blood flow to the skin
and thinner skin)
High body water content (dilutes water-soluble medications)
Decreased protein-binding sites in the blood (until age 1 year), which can
result in an increase in the blood level of protein-binding medications
Physiologic Changes with Aging that Affect Pharmocokinetics
✔✔Increased gastric pH (alkaline)
Decreased gastrointestinal motility and gastric emptying time, resulting in
a slower rate of absorption
Decreased blood flow through the cardiovascular system, liver, kidneys
Decreased kidney function and glomerular filtration rate
Decreased protein-binding sites, resulting in l