NR565 Pharmacology Final Exam Study Guide
Drugs that Reduce Theophylline Levels (CYP3A Inducers)
(Ans - Phenobarbital, phenytoin, rifampin; May need to increase drug level if given
in conjunction; Increase metabolism rate of target drug;
Drugs that Increase Theophylline Levels (CYP3A Inhibitors)
(Ans - Cimetidine, fluoroquinolone antibiotics; May need to reduce drug level if
given in conjunction; These drugs will increase AE associated w/ target drug due
to prolonged activity and decreased metabolism of target drug.
Theophylline Lifespan Concerns
(Ans - Elderly patients: Use with extreme caution in elderly patients as these
patients are at an increased risk of serious toxicity.
Pediatric patients: Dose selection requires caution, and regular monitoring of
concentrations is necessary (especially if the child is younger than 1 year of age)
as the rate of clearance varies significantly in these patients.
Pregnancy: Use cautiously only if risk outweighs benefit
Roflumilast (Daliresp)
(Ans - phosphodiesterase-4 inhibitor (PDE) approved for the treatment of COPD
(and not asthma)

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